Article
A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.
American journal of respiratory and critical care medicine - 1 Sept 2015
Cho Michael H, Castaldi Peter J, Hersh Craig P, Hobbs Brian D, Barr R Graham, Tal-Singer Ruth, Bakke Per, Gulsvik Amund, San José Estépar Raúl, Van Beek Edwin J R, Coxson Harvey O, Lynch David A, Washko George R, Laird Nan M, Crapo James D, Beaty Terri H, Silverman Edwin K
Abstract excerpt
RATIONALE: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences in computed tomography imaging. These differences may be driven by genetic factors. We hypothesized that a genome-wide association study (GWAS) of quantitative imaging would identify loci not previously identified in analyses of COPD or...
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