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Article

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

American journal of respiratory and critical care medicine - 15 Aug 2014

Castaldi Peter J, Cho Michael H, San José Estépar Raúl, McDonald Merry-Lynn N, Laird Nan, Beaty Terri H, Washko George, Crapo James D, Silverman Edwin K

Abstract excerpt

RATIONALE: Emphysema is a heritable trait that occurs in smokers with and without chronic obstructive pulmonary disease. Emphysema occurs in distinct pathologic patterns, but the genetic determinants of these patterns are unknown. OBJECTIVES: To identify genetic loci associated with distinct patt...

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Source

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Identifiers

PMID: 25006744
DOI: 10.1164/rccm.201403-0569OC
PMCID: PMC4214129

Genes

CHRNA3
HHIP
MMP12
TGFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25006744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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