MUC5B promoter polymorphism and interstitial lung abnormalities.

doi:10.1056/NEJMoa1216076

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Article

MUC5B promoter polymorphism and interstitial lung abnormalities.

The New England journal of medicine - 6 Jun 2013

Hunninghake Gary M, Hatabu Hiroto, Okajima Yuka, Gao Wei, Dupuis Josée, Latourelle Jeanne C, Nishino Mizuki, Araki Tetsuro, Zazueta Oscar E, Kurugol Sila, Ross James C, San José Estépar Raúl, Murphy Elissa, Steele Mark P, Loyd James E, Schwarz Marvin I, Fingerlin Tasha E, Rosas Ivan O, Washko George R, O'Connor George T, Schwartz David A

Abstract excerpt

BACKGROUND: A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis. It is not known whether this polymorphism is associated with interstitial lung disease in the general population. METHODS: We performed a blinded assessment of interstitial lung abnormalities detected in 2633 participants in the Framingham Heart Study by means of...

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Identifiers

PMID: 23692170
DOI: 10.1056/NEJMoa1216076
PMCID: PMC3747636

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