Article
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes.
The European respiratory journal - 1 Sept 2017
Putman Rachel K, Gudmundsson Gunnar, Araki Tetsuro, Nishino Mizuki, Sigurdsson Sigurdur, Gudmundsson Elías F, Eiríksdottír Gudny, Aspelund Thor, Ross James C, San José Estépar Raúl, Miller Ezra R, Yamada Yoshitake, Yanagawa Masahiro, Tomiyama Noriyuki, Launer Lenore J, Harris Tamara B, El-Chemaly Souheil, Raby Benjamin A, Cho Michael H, Rosas Ivan O, Washko George R, Schwartz David A, Silverman Edwin K, Gudnason Vilmundur, Hatabu Hiroto, Hunninghake Gary M
Abstract excerpt
The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between the MUC5B genotype and ILA in cohorts with extensive imaging characterisation.We performed ILA phenotyping and MUC5B promoter...
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