MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study.

doi:10.1136/thorax-2021-218139

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Article

MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study.

Thorax - 1 Jun 2023

Kim John S, Manichaikul Ani W, Hoffman Eric A, Balte Pallavi, Anderson Michaela R, Bernstein Elana J, Madahar Purnema, Oelsner Elizabeth C, Kawut Steven M, Wysoczanski Artur, Laine Andrew F, Adegunsoye Ayodeji, Ma Jennie Z, Taub Margaret A, Mathias Rasika A, Rich Stephen S, Rotter Jerome I, Noth Imre, Garcia Christine Kim, Barr R Graham, Podolanczuk Anna J

Abstract excerpt

BACKGROUND: The MUC5B promoter variant (rs35705950) and telomere length are linked to pulmonary fibrosis and CT-based qualitative assessments of interstitial abnormalities, but their associations with longitudinal quantitative changes of the lung interstitium among community-dwelling adults are unknown. METHODS: We used data from participants in the Multi-Ethnic Study of Atherosclerosis with high-attenuation...

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PMID: 36690926
DOI: 10.1136/thorax-2021-218139
PMCID: PMC9899287

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