Article
Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.
Journal of cellular physiology - 1 Feb 2018
Fritz Andrew J, Ghule Prachi N, Boyd Joseph R, Tye Coralee E, Page Natalie A, Hong Deli, Shirley David J, Weinheimer Adam S, Barutcu Ahmet R, Gerrard Diana L, Frietze Seth, van Wijnen Andre J, Zaidi Sayyed K, Imbalzano Anthony N, Lian Jane B, Stein Janet L, Stein Gary S
Abstract excerpt
Alterations in nuclear morphology are common in cancer progression. However, the degree to which gross morphological abnormalities translate into compromised higher-order chromatin organization is poorly understood. To explore the functional links between gene expression and chromatin structure in breast cancer, we performed RNA-seq gene expression analysis on the basal breast cancer progression model based on...
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