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Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

2023-05-11

Abstract excerpt

<h4>Background: </h4> Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome may contribute to matrix metalloprotease (MMP) dysregulation given their key role in invasion, which is the first step of the metastatic process. <h4>Methods: </h4> We combined RNA expression and chromatin...

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Literature Corpus work
2c3fadf2-5bd8-5deb-8162-74671d810565
DOI
10.21203/rs.3.rs-2909119/v1
Open publication

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Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumorsDOI 10.21203/rs.3.rs-2909119/v1
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