Article
Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.
Hereditas - 1 Dec 2014
Brockmann Birgit, Mastel Helena, Oswald Franz, Maier Dieter
Abstract excerpt
Notch signalling mediates intercellular communication, which is effected by the transcription factor CSL, an acronym for vertebrate CBF1/RBP-J, Drosophila Suppressor of Hairless [Su(H)] and C. elegans Lag1. Nuclear import of CBF1/RBP-J depends on co-activators and co-repressors, whereas the export relies on RITA. RITA is a tubulin and CBF1/RBP-J binding protein acting as a negative regulator of Notch signalling...
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