A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.

doi:10.1101/gad.12.15.2269

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Article

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.

Genes & development - 1 Aug 1998

Kao H Y, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner C R, Evans R M, Kadesch T

Abstract excerpt

The Delta-Notch signal transduction pathway has widespread roles in animal development in which it appears to control cell fate. CBF1/RBP-Jkappa, the mammalian homolog of Drosophila Suppressor of Hairless [Su(H)], switches from a transcriptional repressor to an activator upon Notch activation. Th...

Topics

3T3 Cells
Animals
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Histone Deacetylases
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Membrane Proteins
Mice
Models, Biological
Morphogenesis
Mutation
Nuclear Proteins
Nuclear Receptor Co-Repressor 2
Receptor, Notch1

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Identifiers

PMID: 9694793
DOI: 10.1101/gad.12.15.2269
PMCID: PMC317043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9694793-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Receptors, Cell Surface

Receptors, Notch

Repressor Proteins