Article

Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family

2022-06-11

Abstract excerpt

The retinoblastoma protein (Rb) and its homologs p107 and p130 are critical regulators of gene expression during the cell cycle. Functional inactivation of Rb family proteins leads to loss of cell-cycle control and promotes genome instability and proliferation, which are hallmarks of cancer. Rb proteins share a structural domain, known as the “pocket domain”, which mediates association with a large number of cellu...

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Literature Corpus work: 3fc5f16f-dbdd-56a8-bb45-193da8693bc1
DOI: 10.1101/2022.06.10.495386

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