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Article

Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.

Cellular signalling - 1 Aug 2017

Prokop Susanne, Perry Nicole A, Vishnivetskiy Sergey A, Toth Andras D, Inoue Asuka, Milligan Graeme, Iverson Tina M, Hunyady Laszlo, Gurevich Vsevolod V

Abstract excerpt

Non-visual arrestins interact with hundreds of different G protein-coupled receptors (GPCRs). Here we show that by introducing mutations into elements that directly bind receptors, the specificity of arrestin-3 can be altered. Several mutations in the two parts of the central "crest" of the arrestin molecule, middle-loop and C-loop, enhanced or reduced arrestin-3 interactions with several GPCRs in receptor...

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Identifiers

PMID: 28461104
DOI: 10.1016/j.cellsig.2017.04.021
PMCID: PMC5797668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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