Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.

The Journal of biological chemistry - 2 Jun 2000

Oakley R H, Laporte S A, Holt J A, Caron M G, Barak L S

Abstract excerpt

Visual arrestin, betaarrestin1, and betaarrestin2 comprise a family of intracellular proteins that desensitize G protein-coupled receptors (GPCRs). In addition, betaarrestin1 and betaarrestin2 target desensitized receptors to clathrin-coated pits for endocytosis. Whether arrestins differ in their ability to interact with GPCRs in cells is not known. In this study, we visualize the interaction of arrestin family...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrestins
Share to Biological Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to GTP-Binding Proteins

Share to Mutation

Share to Phosphorylation

Share to Protein Binding

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 10748214
DOI: 10.1074/jbc.M910348199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.PMID 10748214Read ↗

Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.Semantic proximity Read ↗

Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.Semantic proximity Read ↗

Receptor/beta-arrestin complex formation and the differential trafficking and resensitization of beta2-adrenergic and angiotensin II type 1A receptors.Semantic proximity Read ↗

Receptor-Arrestin Interactions: The GPCR Perspective.Semantic proximity Read ↗

Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms.Semantic proximity Read ↗

β-Arrestins 1 and 2 are critical regulators of inflammationSemantic proximity Read ↗

Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.Semantic proximity Read ↗

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.Semantic proximity Read ↗

Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.Semantic proximity Read ↗

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.Semantic proximity Read ↗

Targeting arrestin interactions with its partners for therapeutic purposes.Semantic proximity Read ↗

GRK2-mediated receptor phosphorylation and Mdm2-mediated β-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.