Article
Mapping the arrestin-receptor interface. Structural elements responsible for receptor specificity of arrestin proteins.
The Journal of biological chemistry - 9 Jan 2004
Vishnivetskiy Sergey A, Hosey M Marlene, Benovic Jeffrey L, Gurevich Vsevolod V
Abstract excerpt
Arrestins selectively bind to phosphorylated activated forms of their cognate G protein-coupled receptors. Arrestin binding prevents further G protein activation and often redirects signaling to other pathways. The comparison of the high-resolution crystal structures of arrestin2, visual arrestin, and rhodopsin as well as earlier mutagenesis and peptide inhibition data collectively suggest that the elements on...
Topics
- Animals
- Arrestin
- Arrestins
- Cattle
- Cell Line
- Crystallography, X-Ray
- Humans
- Insecta
- Models, Molecular
- Mutagenesis
- Mutation
- Phosphoproteins
- Phosphorylation
- Protein Binding
- Protein Biosynthesis