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Article

Development of Mutant M3 Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins.

Biochemistry - 1 Jul 2025

Meister Jaroslawna, Wanka Lizzy, Perry-Hauser Nicole A, Liu Liu, Iverson Tina M, Gurevich Vsevolod V, Beck-Sickinger Annette G, Kruse Andrew C, Wess Jürgen

Abstract excerpt

The M3 muscarinic acetylcholine (ACh) receptor (M3R), a prototypic class A biogenic amine G protein-coupled receptor (GPCR), regulates various important functions of the CNS and many of the effects of ACh released from peripheral parasympathetic nerves. Agonist-activated M3Rs preferentially couple to G proteins of the Gq family but are also able to bind β-arrestins. The recruitment of β-arrestins by the activated...

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PMID: 40489785
DOI: 10.1021/acs.biochem.5c00036
PMCID: PMC13005129

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