Article
Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes.
Cellular signalling - 1 Jul 2014
Gimenez Luis E, Babilon Stefanie, Wanka Lizzy, Beck-Sickinger Annette G, Gurevich Vsevolod V
Abstract excerpt
Based on the identification of residues that determine receptor selectivity in arrestins and the phylogenetic analysis of the arrestin (arr) family, we introduced fifteen mutations of receptor-discriminator residues in arr-3, which were identified previously using mutagenesis, in vitro binding, and BRET-based recruitment assay in intact cells. The effects of these mutations were tested using neuropeptide Y...
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