Article
The differential engagement of arrestin surface charges by the various functional forms of the receptor.
The Journal of biological chemistry - 10 Feb 2006
Hanson Susan M, Gurevich Vsevolod V
Abstract excerpt
G-protein-coupled receptor signaling is terminated by arrestin proteins that preferentially bind to the activated phosphorylated form of the receptor. Arrestins also bind active unphosphorylated and inactive phosphorylated receptors. Binding to the non-preferred forms of the receptor is important for visual arrestin translocation in rod photoreceptors and the regulation of receptor signaling and trafficking by...
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