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Article

Ryanodine Receptor Structure and Function in Health and Disease.

Sub-cellular biochemistry - 1 Jan 2018

Santulli Gaetano, Lewis Daniel, des Georges Amedee, Marks Andrew R, Frank Joachim

Abstract excerpt

Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca2+) release channels required for the function of many organs including heart and skeletal muscle, synaptic transmission in the brain, pancreatic beta cell function, and vascular tone. In disease, defective function of RyRs due either to stress (hyperadrenergic and/or oxidative overload) or genetic mutations can render the channels leaky to Ca2+...

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Identifiers

PMID: 29464565
DOI: 10.1007/978-981-10-7757-9_11
PMCID: PMC5936639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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