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Article

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule.

Nature - 25 Nov 2010

Tung Ching-Chieh, Lobo Paolo A, Kimlicka Lynn, Van Petegem Filip

Abstract excerpt

Many physiological events require transient increases in cytosolic Ca(2+) concentrations. Ryanodine receptors (RyRs) are ion channels that govern the release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Mutations in RyRs can lead to severe genetic conditions that affect both cardiac and skeletal muscle, but locating the mutated residues in the full-length channel structure has been difficult. Here...

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Share to Calcium signaling and nucleotide metabolism
Share to Cardiac electrophysiology and arrhythmias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21048710
DOI: 10.1038/nature09471

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The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule.PMID 21048710Read ↗

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