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Article

Computational Analysis of Binding Interactions between the Ryanodine Receptor Type 2 and Calmodulin.

The journal of physical chemistry. B - 30 Sept 2021

Greene D'Artagnan, Barton Michael, Luchko Tyler, Shiferaw Yohannes

Abstract excerpt

Mutations in the cardiac ryanodine receptor type 2 (RyR2) have been linked to a variety of cardiac arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). RyR2 is regulated by calmodulin (CaM), and mutations that disrupt their interaction can cause aberrant calcium release, leading to an arrhythmia. It was recently shown that increasing the RyR2-CaM binding affinity could rescue a...

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Identifiers

PMID: 34533024
DOI: 10.1021/acs.jpcb.1c03896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Computational Analysis of Binding Interactions between the Ryanodine Receptor Type 2 and Calmodulin.PMID 34533024Read ↗

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