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Article

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.

Respiratory research - 21 Apr 2017

Kuroda Aoi, Hegab Ahmed E, Jingtao Gao, Yamashita Shuji, Hizawa Nobuyuki, Sakamoto Tohru, Yamada Hideyasu, Suzuki Satoshi, Ishii Makoto, Namkoong Ho, Asakura Takanori, Ozaki Mari, Yasuda Hiroyuki, Hamamoto Junko, Kagawa Shizuko, Soejima Kenzo, Betsuyaku Tomoko

Abstract excerpt

BACKGROUND: Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2*2) results in inactivation of the enzyme and is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer's diseases and some cancers. The effect of this...

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Identifiers

PMID: 28431562
DOI: 10.1186/s12931-017-0554-5
PMCID: PMC5399815

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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