Article

Phenotyping genetic differences in aldehyde dehydrogenase 2 after an alcohol challenge in humans

2020-06-29

Abstract excerpt

Inefficient aldehyde metabolism by an aldehyde dehydrogenase 2 (ALDH2) genetic variant, ALDH2*2 (rs671), increases the risk of esophageal cancer with alcohol consumption. Here we tested the hypothesis that additional genetic differences in ALDH2 besides ALDH2*2 exist resulting in inefficient acetaldehyde metabolism after alcohol consumption. Human volunteers were recruited who self-reported flushing after alcohol....

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Literature Corpus work: 8f81f5d8-931e-52db-b91e-30f1337040cb
DOI: 10.1101/2020.06.26.20137513

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