Article
Association between the aldehyde dehydrogenase 2*2 allele and smoking-related chronic airway obstruction in a Japanese general population: a pilot study.
Toxicology letters - 16 Jul 2015
Morita Kazunori, Masuda Natsuki, Oniki Kentaro, Saruwatari Junji, Kajiwara Ayami, Otake Koji, Ogata Yasuhiro, Nakagawa Kazuko
Abstract excerpt
Aldehyde dehydrogenase 2 (ALDH2) detoxifies exogenous and endogenous toxic aldehydes; however, its protective effect against cigarette smoke in airways is unknown. We therefore examined whether the inactive ALDH2*2 allele is associated with smoking-related chronic airway obstruction. We conducted a cross-sectional study including 684 Japanese participants in a health screening program, and a retrospective...
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