Article

ALDH2 dysfunction accelerates ESCC pathogenesis

2023-04-05

Abstract excerpt

<h4>ABSTRACT</h4> The alcohol metabolite acetaldehyde is a potent human carcinogen. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde in the mitochondria. Acetaldehyde accumulates and causes genotoxic stress in cells expressing the dysfunctional ALDH2 E487K mutant protein linked to ALDH2*2 , the single nucleotide polymorphism highly prevalent amongst East Asians. Chronic alcoho...

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Literature Corpus work: 0a2d5969-1f24-5deb-af4b-fc864a0889be
DOI: 10.1101/2023.04.03.534985

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