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Association of ADH1B and ALDH2 genotypes with the risk of lung adenocarcinoma.

Pharmacogenetics and genomics - 1 Apr 2025

Pan Tzu-Yu, Lee Jui-Ying, Chen Jia-Jen, Liu Yu-Wei, Abishaw A Nishawlini, Su Ming-Wei, Lin Chien-Wei, Hsieh Tusty-Jiuan, Peng Chiung-Yu, Turesky Robert J, Bellamri Medjda, Kwan Aij-Lie, Wu Chia-Fang, Wu Ming-Tsang

Abstract excerpt

OBJECTIVE: The incidence of lung adenocarcinoma (LAD) is increasing worldwide. Single-nucleotide polymorphisms in aldehyde dehydrogenase 2 family member gene ( ALDH2 ) rs671 and alcohol dehydrogenase 1B ( ADH1B ) rs1229984 are common and functionally important genetic variants to metabolize endogenous and exogenous aldehyde chemicals, related to cancer. METHODS: This is a case-control study. A total of 150 newly...

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Source

Identifiers

PMID: 39641391
DOI: 10.1097/FPC.0000000000000555

Genes

ALDH2
ADH1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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