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Article

ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment

18 Nov 2023

Abstract excerpt

The alcohol metabolite acetaldehyde is a potent human carcinogen linked to esophageal squamous cell carcinoma (ESCC) initiation and development. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde in the mitochondria. Acetaldehyde accumulation causes genotoxic stress in cells expressing the dysfunctional ALDH2E487K dominant negative mutant protein linked to ALDH2*2, the single...

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PMID: 37978873
DOI: 10.1093/carcin/bgad085

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