Article

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

2023-08-24

Abstract excerpt

<h4>SUMMARY</h4> The ALDH2*2 (rs671) variant present in >500 million individuals reduces ALDH2 function, impairing aldehyde detoxification. While aldehyde accumulation in these individuals is associated with numerous negative health consequences, a previous study showed a cohort of ALDH2*2 carriers are less likely to develop active pulmonary tuberculosis. Here, we present additional human data that support this...

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Literature Corpus work: 9e67e94d-8e4b-5dfe-8681-5e40e31982e4
DOI: 10.1101/2023.08.24.554661

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