Article
Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development.
Biology direct - 5 May 2016
Mészáros Bálint, Zeke András, Reményi Attila, Simon István, Dosztányi Zsuzsanna
Abstract excerpt
BACKGROUND: Recent advances in sequencing technologies enable the large-scale identification of genes that are affected by various genetic alterations in cancer. However, understanding tumor development requires insights into how these changes cause altered protein function and impaired network regulation in general and/or in specific cancer types. RESULTS: In this work we present a novel method called iSiMPRe...
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