Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice.

Immunology - 1 Sept 2017

Janakiram Naveena B, Mohammed Altaf, Bryant Taylor, Ritchie Rebekah, Stratton Nicole, Jackson Lydgia, Lightfoot Stan, Benbrook Doris M, Asch Adam S, Lang Mark L, Rao Chinthalapally V

Abstract excerpt

The role of the unique T-cell population, natural killer T (NKT) cells, which have similar functions to NK cells in pancreatic cancer (PC), is not yet evaluated. To address the regulatory roles of NKT cells on tumour progression through tumour-associated macrophages (TAM) and their production of microsomal prostaglandin E synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX) in (Kras)-driven pancreatic tumour (KPT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD1d
Share to Arachidonate 5-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma in Situ

Share to CD8 Antigens

Share to Natural Killer T-Cells

Share to Neoplastic Stem Cells

Share to Pancreatic Neoplasms

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 28419443
DOI: 10.1111/imm.12746
PMCID: PMC5543460

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice.PMID 28419443Read ↗

CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in MiceSemantic proximity Read ↗

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancerSemantic proximity Read ↗

ULK1 Knockout suppresses Pancreatic Cancer Progression by Inhibiting Autophagy and Enhancing Anti-tumor ImmunitySemantic proximity Read ↗

Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice.Semantic proximity Read ↗

Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells.Semantic proximity Read ↗

Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia.Semantic proximity Read ↗

Macrophages-induced IL-18-mediated eosinophilia promotes characteristics of pancreatic malignancy.Semantic proximity Read ↗

A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice.Semantic proximity Read ↗

Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant <i>Kras</i> MiceSemantic proximity Read ↗

Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity.Semantic proximity Read ↗

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancerSemantic proximity Read ↗

The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.