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Article

Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice.

Frontiers in immunology - 1 Jan 2018

Kaur Kawaljit, Chang Hui-Hua, Topchyan Paytsar, Cook Jessica Morgan, Barkhordarian Andre, Eibl Guido, Jewett Anahid

Abstract excerpt

The combined/synergistic effect of genetic mutation of KRAS in the pancreas and obesity, a life-style factor on suppression of natural killer (NK) cells at the pre-neoplastic stage of pancreatic cancer has not been investigated and is the subject of this report. Obese mice with KRAS (KC) mutation in the pancreas fed with high-fat calorie diet (HFCD) exhibit severe deficiencies in the NK cell expansion and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29977235
DOI: 10.3389/fimmu.2018.01229
PMCID: PMC6021953

Genes

KRAS

Provenance

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Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice.PMID 29977235Read ↗

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