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Article

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

2017-12-15

Abstract excerpt

The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune attack is often provided by the tumour microenvironment that suppresses and/or excludes cytotoxic CD8 + T cells. Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease with unmet needs, yet the immuno-protective role of the metastati...

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Identifiers and source

Literature Corpus work
83056597-ed0b-5b75-92ee-7e8b349ab94a
DOI
10.1101/234906
Open publication

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Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancerDOI 10.1101/234906
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