Article
A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice.
Gastroenterology - 1 Jun 2014
Keenan Bridget P, Saenger Yvonne, Kafrouni Michel I, Leubner Ashley, Lauer Peter, Maitra Anirban, Rucki Agnieszka A, Gunderson Andrew J, Coussens Lisa M, Brockstedt Dirk G, Dubensky Thomas W, Hassan Raffit, Armstrong Todd D, Jaffee Elizabeth M
Abstract excerpt
BACKGROUND & AIMS: Premalignant lesions and early stage tumors contain immunosuppressive microenvironments that create barriers for cancer vaccines. Kras(G12D/+);Trp53(R172H/+);Pdx-1-Cre (KPC) mice, which express an activated form of Kras in pancreatic tissues, develop pancreatic intraepithelial neoplasms (PanIN) that progress to pancreatic ductal adenocarcinoma (PDA). We used these mice to study immune...
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