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Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant <i>Kras</i> Mice

2020-12-07

Abstract excerpt

Pro-obesity high-fat diet is linked with an increased incidence of pancreatic cancers, but the molecular underpinnings of this association remain poorly understood. Here, we report that PPARD is upregulated in pancreatic intraepithelial neoplasia lesions (PanINs) at early stages of pancreatic tumorigenesis in humans and mutant Kras mice. Transgenic overexpression of Ppard in pancreatic epithelial cells drasticall...

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Identifiers and source

Literature Corpus work
77f2fb69-d5f1-5ac7-ae12-c40b2501043c
DOI
10.1101/2020.12.04.412320
Open publication

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Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant <i>Kras</i> MiceDOI 10.1101/2020.12.04.412320
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