Article
Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity.
JCI insight - 9 May 2022
Pham Thao Nd, Spaulding Christina, Shields Mario A, Metropulos Anastasia E, Shah Dhavan N, Khalafalla Mahmoud G, Principe Daniel R, Bentrem David J, Munshi Hidayatullah G
Abstract excerpt
To elicit effective antitumor responses, CD8+ T cells need to infiltrate tumors and sustain their effector function within the immunosuppressive tumor microenvironment (TME). Here, we evaluate the role of MNK activity in regulating CD8+ T cell infiltration and antitumor activity in pancreatic and thyroid tumors. We first show that human pancreatic and thyroid tumors with increased MNK activity are associated with...
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