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Article

Macrophages-induced IL-18-mediated eosinophilia promotes characteristics of pancreatic malignancy.

Life science alliance - 1 Aug 2021

Kandikattu Hemanth Kumar, Manohar Murli, Verma Alok Kumar, Kumar Sandeep, Yadavalli Chandra Sekhar, Upparahalli Venkateshaiah Sathisha, Mishra Anil

Abstract excerpt

Reports indicate that accumulated macrophages in the pancreas are responsible for promoting the pathogenesis of chronic pancreatitis (CP). Recently, macrophage-secreted cytokines have been implicated in promoting pancreatic acinar-to-ductal metaplasia (ADM). This study aims to establish the role of accumulated macrophage-activated NLRP3-IL-18-eosinophil mechanistic pathway in promoting several characteristics of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34183442
DOI: 10.26508/lsa.202000979
PMCID: PMC8321680

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