Article
The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice.
Oncoimmunology - 1 Jan 2023
Al Olabi Raghd, Hendy Abd El Aziz, Alkassab Mohamad Basem, Alnajm Karla, Elias Manahel, Ibrahim Mary, Carlyle James R, Makrigiannis Andrew P, Rahim Mir Munir A
Abstract excerpt
Natural killer (NK) cells are an important component of anti-cancer immunity, and their activity is regulated by an array of activating and inhibitory receptors. In mice, the inhibitory NKR-P1B receptor is expressed in NK cells and recognizes the C-type lectin-related protein-b (Clr-b) ligand. NKR-P1B:Clr-b interactions represent a 'missing-self' recognition system to monitor cellular levels of Clr-b on healthy...
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