Article

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

2025-05-27

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer for which there is a critical need to identify novel therapeutic targets. Herein we define PSGL-1 as a checkpoint inhibitor using a syngeneic orthotopic model of PDAC. As with PDAC patients, CD8 + T cells within murine PDAC tumors expressed high levels of PSGL-1. PSGL-1 -/- mice displayed striking T cell-dependent control of primary tumors and lung metas...

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Literature Corpus work: fe3184e1-bf10-590a-b002-977ef93a4efc
DOI: 10.1101/2025.05.22.655365

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