Article
Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia.
Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2024
Strickland Lincoln N, Liu Wendao, Hussein Usama, Mardik Nicolette, Chen Xian, Mills Tingting, Vornik Lana A, Savage Michelle I, Sei Shizuko, Clifford John, Eltzschig Holger K, Brown Powel H, Zhao Zhongming, McAllister Florencia, Bailey-Lundberg Jennifer M
Abstract excerpt
Immunoprevention is an emerging consideration for solid tumors, including pancreatic ductal adenocarcinoma (PDAC). We and others have shown that Kras mutations in genetic models of spontaneous pancreatic intraepithelial neoplasia (PanIN), which is a precursor to PDAC, results in CD73 expression in the neoplastic epithelium and some populations of infiltrating immune cells, including macrophages and CD8 T cells....
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