Article

ULK1 Knockout suppresses Pancreatic Cancer Progression by Inhibiting Autophagy and Enhancing Anti-tumor Immunity

2025-05-13

Abstract excerpt

<title>Abstract</title> <p>Autophagy plays a dual role in cancer, acting as a tumor suppressor and promoter depending on tumor stage and context. While core autophagy genes such as Atg5 and Atg7, the role of Unc-51-like kinase 1 (ULK1) —a key autophagy initiator-remains poorly understood in pancreatic ductal adenocarcinoma (PDAC). In this study, we investigated the role of ULK1 using tissue-specific deletion in G...

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Literature Corpus work: 8506c0b9-3442-525b-9133-711c9b78b799
DOI: 10.21203/rs.3.rs-6438501/v1

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