Article
Natural non-homologous recombination led to the emergence of a duplicated V3-NS5A region in HCV-1b strains associated with hepatocellular carcinoma.
PloS one - 1 Jan 2017
Le Guillou-Guillemette Hélène, Pivert Adeline, Bouthry Elise, Henquell Cécile, Petsaris Odile, Ducancelle Alexandra, Veillon Pascal, Vallet Sophie, Alain Sophie, Thibault Vincent, Abravanel Florence, Rosenberg Arielle A, André-Garnier Elisabeth, Bour Jean-Baptiste, Baazia Yazid, Trimoulet Pascale, André Patrice, Gaudy-Graffin Catherine, Bettinger Dominique, Larrat Sylvie, Signori-Schmuck Anne, Saoudin Hénia, Pozzetto Bruno, Lagathu Gisèle, Minjolle-Cha Sophie, Stoll-Keller Françoise, Pawlotsky Jean-Michel, Izopet Jacques, Payan Christopher, Lunel-Fabiani Françoise, Lemaire Christophe
Abstract excerpt
BACKGROUND: The emergence of new strains in RNA viruses is mainly due to mutations or intra and inter-genotype homologous recombination. Non-homologous recombinations may be deleterious and are rarely detected. In previous studies, we identified HCV-1b strains bearing two tandemly repeated V3 regions in the NS5A gene without ORF disruption. This polymorphism may be associated with an unfavorable course of liver...
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