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Article

Characterization and evolution of NS5A quasispecies of hepatitis C virus genotype 1b in patients with different stages of liver disease.

Journal of medical virology - 1 Oct 2003

Franco Sandra, Giménez-Barcons Mireia, Puig-Basagoiti Francesc, Furcic Ivana, Sánchez-Tapias José-María, Rodés Juan, Sáiz Juan-Carlos

Abstract excerpt

The quasispecies nature of hepatitis C virus (HCV) is thought to play a central role in modulating viral functions. Recent work has linked NS5A protein with viral replication, resistance to interferon (IFN), and control of cellular growth, probably through the interaction of its protein kinase R (double stranded RNA-activated protein kinase, PKR) binding domain (PKR-bd) with cellular PKR, but knowledge of how...

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Identifiers

PMID: 12938193
DOI: 10.1002/jmv.10470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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