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Article

Productive Homologous and Non-homologous Recombination of Hepatitis C Virus in Cell Culture

28 Mar 2013

Abstract excerpt

Genetic recombination is an important mechanism for increasing diversity of RNA viruses, and constitutes a viral escape mechanism to host immune responses and to treatment with antiviral compounds. Although rare, epidemiologically important hepatitis C virus (HCV) recombinants have been reported. In addition, recombination is an important regulatory mechanism of cytopathogenicity for the related pestiviruses....

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PMID: 23555245
DOI: 10.1371/journal.ppat.1003228

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