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Article

Molecular evolution of hepatitis A virus in a human diploid cell line.

World journal of gastroenterology - 14 Sept 2007

Tang Cai-Hua, Mao Jiang-Sen, Chai Shao-Ai, Chen Yong, Zhuang Fang-Cheng

Abstract excerpt

AIM: To investigate the hotspots, direction, and the time course of evolution of hepatitis A virus in the process of consecutive cell culture passage in human KMB17 diploid cells. METHODS: Wild type hepatitis A virus H2w was serially propagated in KMB17 cells until passage 30, and the full-length genomes of H2w and its six chosen progenies were determined by directly sequencing RT-PCR products amplified from...

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Source

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Identifiers

PMID: 17729420
DOI: 10.3748/wjg.v13.i34.4630
PMCID: PMC4611841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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