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Article

NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b.

Virology journal - 23 Jun 2011

Sarwar Muhammad T, Kausar Humera, Ijaz Bushra, Ahmad Waqar, Ansar Muhammad, Sumrin Aleena, Ashfaq Usman A, Asad Sultan, Gull Sana, Shahid Imran, Hassan Sajida

Abstract excerpt

BACKGROUND: The 9.6 kb long RNA genome of Hepatitis C virus (HCV) is under the control of RNA dependent RNA polymerase, an error-prone enzyme, for its transcription and replication. A high rate of mutation has been found to be associated with RNA viruses like HCV. Based on genetic variability, HCV has been classified into 6 different major genotypes and 11 different subtypes. However this classification system...

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PMID: 21696641
DOI: 10.1186/1743-422X-8-317
PMCID: PMC3145594

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