Article
Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells.
Scientific reports - 4 Apr 2017
Berton Stefania, Cusan Martina, Segatto Ilenia, Citron Francesca, D'Andrea Sara, Benevol Sara, Avanzo Michele, Dall'Acqua Alessandra, Schiappacassi Monica, Bristow Robert G, Belletti Barbara, Baldassarre Gustavo
Abstract excerpt
Genomic instability represents a typical feature of aggressive cancers. Normal cells have evolved intricate responses to preserve genomic integrity in response to stress, such as DNA damage induced by γ-irradiation. Cyclin-dependent kinases (CDKs) take crucial part to these safeguard mechanisms, but involvement of CDK-inhibitors, such as p27Kip1, is less clear. We generated immortalized fibroblasts from p27kip1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.