Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p27Kip1 and human cancers: A reappraisal of a still enigmatic protein.

Cancer letters - 10 Sept 2017

Bencivenga Debora, Caldarelli Ilaria, Stampone Emanuela, Mancini Francesco Paolo, Balestrieri Maria Luisa, Della Ragione Fulvio, Borriello Adriana

Abstract excerpt

p27Kip1 is a cell cycle regulator firstly identified as a cyclin-dependent kinase inhibitor. For a long time, its function has been associated to cell cycle progression inhibition at G1/S boundary in response to antiproliferative stimuli. The picture resulted complicated by the discovery that p27Kip1 is an intrinsically unstructured protein, with numerous CDK-dependent and -independent functions and involvement...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasms

Share to Protein Conformation

Share to Protein Processing, Post-Translational

Share to Signal Transduction

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 28687353
DOI: 10.1016/j.canlet.2017.06.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p27Kip1 and human cancers: A reappraisal of a still enigmatic protein.PMID 28687353Read ↗

The function of p27 KIP1 during tumor development.Semantic proximity Read ↗

p27Kip1 and Tumors: Characterization of CDKN1B Variants Identified in MEN4 and Breast CancerSemantic proximity Read ↗

p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human CancersSemantic proximity Read ↗

Understanding p27<sup>kip1</sup>Deregulation in Cancer: Downregulation or Mislocalizaiton?Semantic proximity Read ↗

p57Kip2 and Cancer: Time for a Critical AppraisalSemantic proximity Read ↗

p27 as a Transcriptional Regulator: New Roles in Development and CancerSemantic proximity Read ↗

Regulation of the Cdk inhibitor p27 and its deregulation in cancerSemantic proximity Read ↗

A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancersSemantic proximity Read ↗

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted TherapiesSemantic proximity Read ↗

p21 and p27: roles in carcinogenesis and drug resistanceSemantic proximity Read ↗

p27 in Cell Cycle Control and CancerSemantic proximity Read ↗

The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.