Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.

Oncogene - 12 Aug 2004

Deans Andrew J, Simpson Kaylene J, Trivett Melanie K, Brown Melissa A, McArthur Grant A

Abstract excerpt

One common characteristic of breast cancers arising in carriers of the predisposition gene BRCA1 is a loss of expression of the CDK inhibitor p27(Kip1) (p27), suggesting that p27 interacts epistatically with BRCA1. To investigate this relationship, we examined expression of p27 in mice expressing a dominant negative allele of Brca1 (MMTV-trBr) in the mammary gland. While these mice rarely develop tumors, they...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Epithelial Cells

Share to Genes, BRCA1

Share to Mammary Glands, Human

Share to Mammary Tumor Virus, Mouse

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15208652
DOI: 10.1038/sj.onc.1207805

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.PMID 15208652Read ↗

Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.Semantic proximity Read ↗

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice.Semantic proximity Read ↗

Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.Semantic proximity Read ↗

The function of p27 KIP1 during tumor development.Semantic proximity Read ↗

Identification of oncogenes collaborating with p27 <sup>Kip1</sup> loss by insertional mutagenesis and high-throughput insertion site analysisSemantic proximity Read ↗

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Semantic proximity Read ↗

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.Semantic proximity Read ↗

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells.Semantic proximity Read ↗

Cdk inhibitor p27Kip1 and hormone dependence in breast cancer.Semantic proximity Read ↗

p27 in Cell Cycle Control and CancerSemantic proximity Read ↗

p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability.Semantic proximity Read ↗

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.