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Article

Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice

13 Sept 2017

Abstract excerpt

Polo-like kinase 1 (Plk1), a serine/threonine protein kinase normally expressed in mitosis, is frequently up-regulated in multiple types of human tumors regardless of the cell cycle stage. However, the causal relationship between Plk1 up-regulation and tumorigenesis is incompletely investigated. To this end, using a conditional expression system, here we generated Plk1 transgenic mouse lines to examine the role...

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PMID: 28900036
DOI: 10.1074/jbc.m117.810960

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