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Article

LKB1 preserves genome integrity by stimulating BRCA1 expression.

Nucleic acids research - 1 Jan 2015

Gupta Romi, Liu Alex Y, Glazer Peter M, Wajapeyee Narendra

Abstract excerpt

Serine/threonine kinase 11 (STK11, also known as LKB1) functions as a tumor suppressor in many human cancers. However, paradoxically loss of LKB1 in mouse embryonic fibroblast results in resistance to oncogene-induced transformation. Therefore, it is unclear why loss of LKB1 leads to increased predisposition to develop a wide variety of cancers. Here, we show that LKB1 protects cells from genotoxic stress. Cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25488815
DOI: 10.1093/nar/gku1294
PMCID: PMC4288185

Genes

BRCA1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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