Article
Understanding p27<sup>kip1</sup>Deregulation in Cancer: Downregulation or Mislocalizaiton?
1 Nov 2002
Abstract excerpt
There is considerable evidence that the inactivation of the cyclin-dependent kinase inhibitor p27(kip1) is a fundamental step for the development of human malignancies. In particular, reduced expression of p27(kip1), due to increased protein degradation, correlates with poor prognosis of patients affected by various types of cancer. The purpose of this mini-review is to present an overview of the current...