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Targeting RB1 Loss in Cancers

25 Jul 2021

Abstract excerpt

Retinoblastoma protein 1 (RB1) is encoded by a tumor suppressor gene that was discovered more than 30 years ago. Almost all mitogenic signals promote cell cycle progression by braking on the function of RB1 protein through mono- and subsequent hyper-phosphorylation mediated by cyclin-CDK complexes. The loss of RB1 function drives tumorigenesis in limited types of malignancies including retinoblastoma and small...

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PMID: 34359636
DOI: 10.3390/cancers13153737

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